Psilocybin to prevent alcohol relapse with depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether psilocybin (a psychedelic compound) can help people with severe alcohol use disorder stay sober longer, especially if they also have depression. Participants receive guided psilocybin sessions alongside counseling to reduce the risk of returning to heavy drinking.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with severe alcohol use disorder and depression (specific screening scores required)
- Recently stopped drinking (within the last 10–60 days before joining)
- Had at least one day of heavy drinking in the last 4 weeks before quitting
- Not pregnant, planning pregnancy, or breastfeeding during the study
- No other active substance use (except tobacco), no schizophrenia or bipolar disorder, and no recent psychedelic use
- Medically stable: no serious heart, liver, seizure, or uncontrolled diabetes conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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