Applying PRF gel before radiation for head and neck cancer
Part of Cancer clinical trials.
This trial tests whether applying a special gel made from your own blood (platelet-rich fibrin, or PRF) to the tooth sockets after extraction can help the gums heal better before radiation therapy starts. It's for people with head and neck cancer who need to have teeth removed on both sides of the jaw.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have head and neck cancer and are scheduled to receive radiation therapy.
- You will have teeth on both sides of your jaw removed (bilateral tooth extraction).
- The teeth being removed are similar in size.
- The extractions will be done gently, without cutting into the gum (atraumatic, no flap surgery).
- You are 18 years old or older.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a special blood-derived gel called leukocyte and platelet-rich fibrin (L-PRF) to help prevent jawbone damage after tooth extraction in people who have had head or neck radiation or take bone-strengthening medications. L-PRF is made from a small amount of your blood and placed in the extraction socket to promote healing.
This study tests whether using a concentrate of your own platelets (cells that help blood clot and heal) in the tooth socket after removal improves healing and reduces the risk of a jaw bone condition called MRONJ. It may be an option if you are at higher risk for MRONJ due to certain medications.
This study tests whether a special blood clot placed in the tooth socket after a dental extraction can help prevent a jaw bone problem called osteoradionecrosis, which can happen in people who had radiation for head and neck cancer. If you need a tooth pulled in an area that was previously radiated, this treatment might reduce the risk of bone damage and help you heal better.
This study tests if a gel made from your own blood can help your gums heal faster after a back tooth is removed. It is for patients getting dental care at the University of Nebraska Medical Center.
This study tests whether placing a special clot made from your own blood (called Platelet Rich Fibrin) into the socket after a tooth extraction helps the bone heal better for a future dental implant.
This study looks at how age affects healing after a tooth is removed and replaced with a bone graft using Platelet-Rich Fibrin (PRF), a natural substance from your own blood that helps healing. It may help you if you need a molar removed and plan to get an implant later.
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