Platelet-rich fibrin to protect the jaw after tooth removal
Treatments studied
Part of Injuries & trauma clinical trials.
This study tests whether a special blood clot placed in the tooth socket after a dental extraction can help prevent a jaw bone problem called osteoradionecrosis, which can happen in people who had radiation for head and neck cancer. If you need a tooth pulled in an area that was previously radiated, this treatment might reduce the risk of bone damage and help you heal better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have had radiation therapy for head and neck cancer.
- You need at least one tooth removed in an area of the jaw that received radiation.
- You are willing and able to come to all follow-up visits.
- You do not have an active infection (abscess) at the tooth extraction site.
- You do not have a blood disorder, are not on certain immune-suppressing or bone-affecting medications, are not a current tobacco user, and are not pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a special blood-derived gel called leukocyte and platelet-rich fibrin (L-PRF) to help prevent jawbone damage after tooth extraction in people who have had head or neck radiation or take bone-strengthening medications. L-PRF is made from a small amount of your blood and placed in the extraction socket to promote healing.
This study tests whether using a concentrate of your own platelets (cells that help blood clot and heal) in the tooth socket after removal improves healing and reduces the risk of a jaw bone condition called MRONJ. It may be an option if you are at higher risk for MRONJ due to certain medications.
This study compares two methods for preserving the jawbone after having a tooth pulled: using the patient's own blood cells (PRF) versus a standard bone graft with a membrane. The goal is to see which method works better for maintaining bone shape and density, which can help with future dental implants or other restorations.
This study tests a technique to preserve the jawbone after a tooth is removed, so there is enough bone left to place a dental implant later. It may help people who need a tooth extraction and want to get a dental implant in the future.
This study compares different ways to preserve the bone where a tooth is removed, which may help keep the area ready for future implants or other dental work. If you're having a tooth pulled due to gum disease, this trial could help maintain your jawbone and support better healing.
This trial tests whether a special dressing made from your own blood (called L-PRF) can help your jaw heal better after surgery for medication-related bone damage. It's for people who need surgery for this condition and aims to improve recovery.
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