Clin2
NCT06407310Possibly a fitNot yet recruiting

Immunotherapy and chemotherapy before surgery for early triple-negative breast cancer

Triple Negative Breast Cancer

Treatments studied

Part of Cancer, Skin clinical trials.

This trial tests whether giving pembrolizumab (an immunotherapy drug) together with chemotherapy before surgery can help treat early-stage triple-negative breast cancer. It aims to improve outcomes by shrinking the tumor before removal.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
25 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have been diagnosed with stage I or II triple-negative breast cancer.
  • Your tumor is larger than 1 cm.
  • You are willing to provide a new tissue sample (biopsy) from your tumor.
  • You have not had prior chemotherapy, radiation, or immunotherapy for this cancer within the last 24 months.
  • You are in generally good health, with a performance status of 0 or 1 (able to do daily activities).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06845319Recruiting· Phase 2
Chemo-immunotherapy before surgery for triple-negative breast cancer

This trial tests a new combination of chemotherapy and immunotherapy that avoids a class of drugs called anthracyclines, which can be hard on the heart. The goal is to shrink tumors before surgery for people with triple-negative or low-hormone-receptor breast cancer.

Charleston, South Carolina
NCT06318897Recruiting· Phase 2
Immunotherapy with chemo for early triple-negative breast cancer

This trial tests a combination of an immunotherapy drug (pembrolizumab) plus two chemotherapy drugs (carboplatin and paclitaxel) given before surgery for people with early-stage, triple-negative breast cancer. The goal is to see if this treatment helps shrink or eliminate the tumor before it's removed.

Houston, Texas
NCT06817525Recruiting· Phase 2
Chemo and immunotherapy before surgery for early triple-negative breast cancer

This trial tests whether a combination of chemotherapy drugs (nab-paclitaxel and carboplatin) plus an immunotherapy drug (PD1 inhibitor) given before surgery can help treat early-stage triple-negative breast cancer. It aims to improve outcomes by using these treatments before the main surgery.

Zhengzhou, Henan
NCT06078384Recruiting· Phase 2
Pembrolizumab and chemo for early-stage triple-negative breast cancer

This trial studies whether adding pembrolizumab (an immunotherapy) to standard chemotherapy after surgery can improve outcomes for people with early-stage triple-negative breast cancer. The treatment you receive depends on the level of immune cells (TILs) found in your tumor.

Amiens
NCT06371807Not yet recruiting· Phase 2
Chemotherapy plus pembrolizumab before surgery for high-risk triple-negative breast cancer

This trial tests two different sequences of chemotherapy combined with pembrolizumab (an immunotherapy drug) given before surgery for high-risk triple-negative breast cancer. The goal is to see which sequence works better at shrinking or eliminating the tumor.

Lisbon
NCT07486687Not yet recruiting· Phase 3
Extra pembrolizumab after surgery for early-stage triple-negative breast cancer

This trial tests if giving more of the immunotherapy drug pembrolizumab (Keytruda) after surgery helps people with early-stage triple-negative breast cancer that did not completely disappear with the initial chemotherapy plus immunotherapy. This is for patients who still have some cancer left after surgery, to reduce the chance of it coming back.

Hear when a new Triple Negative Breast Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.