Stem cell collection for sickle cell disease using motixafortide
Treatments studied
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This trial tests a drug called motixafortide that helps move stem cells from your bone marrow into your blood so they can be collected for future gene therapy. It is for adults with severe sickle cell disease who may benefit from this treatment approach.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe sickle cell disease and are 18 or older.
- You are willing to donate your own stem cells for future gene therapy.
- You have a central line in place, can have apheresis without one, or agree to have a central line placed if needed.
- You are generally healthy enough (score of 80 or above on a standard health scale).
- Your blood counts, kidney, liver, and heart function meet specified levels.
- You have tested negative for infections like syphilis, hepatitis B/C, HIV, and HTLV.
- You are not pregnant and agree to use effective contraception if of childbearing age.
- You are willing to stop hydroxyurea for 30 days before the study drug.
- You do not have an active infection, cancer history, or prior transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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