Stem cell collection for sickle cell disease
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This trial tests a drug that helps your body release stem cells so they can be collected for a future bone marrow transplant. It may help make the transplant process safer and more effective for people with sickle cell disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 25 years old.
- You have sickle cell disease and a doctor has said you need a bone marrow transplant.
- You are generally healthy enough for a transplant (e.g., good heart, kidney, and liver function).
- You have not had a major surgery or been in the hospital in the past month.
- You are willing to pause certain medications (like hydroxyurea) for a month before starting.
- You are not pregnant and will use two forms of birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a drug called motixafortide that helps move stem cells from your bone marrow into your blood so they can be collected for future gene therapy. It is for adults with severe sickle cell disease who may benefit from this treatment approach.
This early-phase study tests whether a “half-matched” donor bone marrow transplant, with special medicines to calm the immune system before transplant, can improve outcomes for people with sickle cell disease. It may help high-risk patients who have frequent complications and don’t have a fully matched donor.
This Phase 2 study tests a type of stem cell transplant that uses donor immune cells that have been specially “tweaked” to help treat sickle cell disease. It may help prevent serious sickle cell complications, but it requires careful matching and screening of organs and pregnancy status.
This trial tests whether a stem cell transplant from a partially gene-matched family member can cure severe sickle cell disease in children and young adults. The transplant uses a new approach that may work even when a perfectly matched sibling isn't available, and it might help patients whose sickle cell is causing serious complications like strokes, organ damage, or frequent pain crises.
This trial tests a stem cell transplant from a half-matched donor using a strong conditioning regimen and a drug called defibrotide to protect organs. It aims to cure sickle cell disease in patients who have had serious complications like stroke, chest syndrome, or frequent pain episodes.
This trial studies a stem cell transplant approach for children with sickle cell disease, using a sibling donor whose blood type is not compatible. It aims to see if this transplant method can safely reduce serious sickle cell complications.
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