Testing doxycycline with chemo for breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests whether adding the antibiotic doxycycline to standard chemotherapy before surgery can better target breast cancer stem cells in people with ER-positive, HER2-negative breast cancer. The goal is to improve treatment response.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of breast cancer called ER-positive, HER2-negative (hormone receptor positive).
- Your tumor is at least 2 cm in size and has not spread to distant organs.
- You are scheduled to receive standard chemotherapy (epirubicin, cyclophosphamide, paclitaxel) before surgery.
- You are able to swallow tablets and have adequate organ function (kidney, liver, bone marrow).
- You have not taken doxycycline or similar antibiotics within the last month.
- You are not pregnant or breastfeeding, and agree to use effective birth control during and for 12 months after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving chemotherapy before surgery, guided by the genetic profile of your tumor, can improve outcomes for a specific type of HER2-positive breast cancer. It aims to tailor treatment to each person's cancer biology.
This phase 3 trial compares two pre-surgery treatment plans for people with HER2-positive invasive breast cancer that has spread to nearby lymph nodes. It aims to see which plan works better to shrink the tumor before surgery and improve outcomes.
This trial is comparing two types of chemotherapy (standard taxane vs a newer albumin-bound paclitaxel) given after surgery to see which is better at preventing breast cancer from returning. It is for women with HER2-negative breast cancer that has a high risk of coming back.
This trial tests a combination of targeted drugs and chemotherapy before surgery for HER2-positive breast cancer. It aims to see if this approach can shrink or eliminate the tumor, making surgery more effective.
This trial tests different combinations of targeted therapy and chemotherapy before surgery for HER2-positive breast cancer. It uses a special PET scan to see how well the treatment is working and to help choose the best treatment plan for each person.
This Phase 1 study tests different chemotherapy approaches in people with breast cancer that has been surgically removed but is early stage. It aims to find a chemotherapy plan that’s safe and works well right after surgery.
Hear when a new Breast cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.