Clin2
NCT06454669Possibly a fitRecruiting

Dronabinol added to opioids for chronic low back pain

Low Back PainChronic PainBack Injuries

Treatments studied

Part of Injuries & trauma, Pain clinical trials.

This trial tests whether adding dronabinol (a prescription medication derived from cannabis) to your current opioid pain treatment can help reduce chronic low back pain more effectively. It is for people who have had persistent low back pain for at least 3 months and are already on a stable opioid regimen.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
75 people
Ages
18 years to 64 years
Study type
Interventional

Who can take part

  • You are between 18 and 64 years old.
  • You have had low back pain for at least 3 months that has been present on most days for the past 6 months.
  • You are on a stable dose of opioid pain medication (and no other new pain meds) for at least 3 months.
  • You are willing to stop using marijuana, CBD, or any other cannabis products for the study.
  • You are not pregnant, breastfeeding, or planning pregnancy, and you agree to use effective birth control if applicable.
  • You do not have a current major psychiatric illness, history of substance abuse, seizures, or certain heart conditions.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06544291Recruiting· Phase 2
THC and CBD for pain and opioid use disorder

This study tests whether a combination of THC and CBD can help people who have both opioid use disorder and chronic low back pain. You would need to be on a stable dose of methadone and have used cannabis at least once in your life.

New Haven, Connecticut
NCT05607381Recruiting
Meditation program study for opioid-treated chronic low back pain

This trial studies how meditation may change brain activity and help people with long-lasting low back pain who are already taking prescription opioids. The goal is to understand the “neural” (brain) effects of meditation to improve pain treatment.

La Jolla, California
NCT07783295Not yet recruiting· Phase 2
Cannabis extract for chronic pain and bone health in women

This study tests whether a full-spectrum cannabis extract (a whole-plant product containing many natural compounds) can help relieve chronic pain and improve markers of bone health in women. If you join, you'll take the extract and your pain and bone health will be monitored.

São Paulo, São Paulo
NCT06666621Recruiting· Phase 4
Naloxone injection for low back pain

This trial tests whether naloxone, a drug that blocks opioid effects, can change how your body responds to pain injections in the lower back. It may help find new ways to treat low back pain that hasn't improved with physical therapy or oral medications.

Nashville, Tennessee
NCT07641504Recruiting· Phase 2
Testing LY4065967 for chronic low back pain relief

This study tests whether a new medication called LY4065967 can reduce chronic low back pain. Researchers want to see if it works better than current treatments for people who have had lower back pain for at least 3 months.

Birmingham, Alabama
NCT04025359Recruiting· Early Phase 1
Test dronabinol for pain responses in people on opioid treatment

This early-stage study tests whether dronabinol (a form of THC) changes pain perception in people with opioid use disorder who are already stable on methadone or buprenorphine. It may help researchers understand whether this treatment affects pain and drug-related outcomes in a safer, controlled way.

West Haven, Connecticut

Hear when a new Low Back Pain trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.