Epcoritamab with CAR T cells for large B-cell lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of two immune therapies—epcoritamab (a bispecific antibody) and CAR T cells—for people with large B-cell lymphoma whose cancer didn't respond to first treatment. The goal is to see if this combination works better than CAR T cells alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your lymphoma did not improve after your first standard treatment (which included chemotherapy and an antibody like rituximab).
- You are willing to receive a type of CAR T-cell therapy that is already approved (like Kymriah, Breyanzi, or Yescarta).
- You have a PET or CT scan showing at least one clearly measurable tumor.
- You do not have an active serious infection like hepatitis B, hepatitis C, or HIV, or a serious autoimmune disease that requires immune-suppressing drugs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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