Epcoritamab and chemo before stem cell transplant for relapsed large B-cell lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of a new immunotherapy drug called epcoritamab with chemotherapy, followed by a stem cell transplant and more epcoritamab, for people whose large B-cell lymphoma has returned after initial treatment. The goal is to see if this approach can help more people achieve remission and stay in remission.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older and have a type of aggressive B-cell lymphoma that has come back after at least one round of chemotherapy combined with immunotherapy.
- Your doctor must confirm you are healthy enough to receive a stem cell transplant using your own cells.
- You must have at least one tumor that can be measured on a CT scan and is also active on a PET scan.
- Your lymphoma must have a protein called CD20 on its surface, which will be checked on a recent biopsy.
- You must have adequate kidney and liver function, and your blood counts must be high enough (with possible support from transfusions or growth factors).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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