Sonrotoclax, Zanubrutinib, and CD20 Antibody for Untreated Mantle Cell Lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a combination of three drugs—sonrotoclax, zanubrutinib, and a CD20 antibody—as a first treatment for mantle cell lymphoma. It aims to see if this new combination is safe and effective for patients who have not yet received any treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with mantle cell lymphoma (MCL) and have not had any previous treatment for it.
- You are able to care for yourself (ECOG performance status of 2 or less).
- You have adequate bone marrow, kidney, and liver function as shown by blood tests.
- You do not have untreated hepatitis B or C, or HIV infection.
- You have not had a prior stem cell transplant, CAR-T therapy, or treatment with a BCL2 or BTK inhibitor.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new combination of two targeted therapies for people with mantle cell lymphoma that has come back or hasn't responded to prior treatment. It aims to see if adding sonrotoclax to zanubrutinib works better than zanubrutinib alone.
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