Drug combo plus radiation for muscle-invasive bladder cancer
Treatments studied
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with bladder cancer that has grown into the muscle layer. The goal is to see if this treatment can kill the cancer while avoiding the need for bladder removal surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have bladder cancer that has grown into the muscle layer of the bladder (called muscle-invasive bladder cancer).
- You are not able to have surgery to remove the bladder, or you choose not to have surgery.
- You are willing to have radiation therapy to the bladder.
- You have had a recent biopsy (TURBT) that shows live cancer cells in your bladder.
- Your cancer has not spread to distant parts of your body (like lungs, liver, or bones), and you have not had certain types of cancer treatment in the last 12 months.
- You have good kidney and liver function, and your blood counts are within certain ranges.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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