Orelabrutinib plus rituximab for marginal zone lymphoma
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of two targeted therapies—oralebrutinib (a pill that blocks a protein in cancer cells) and rituximab (an antibody infusion)—for people with marginal zone lymphoma that has returned or cannot be treated with local therapies. The goal is to see if this combo works well and is safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You must have marginal zone lymphoma (a slow-growing B-cell lymphoma) that is CD20-positive.
- Your lymphoma must have come back, gotten worse, or not been suitable for local treatments like surgery or radiation.
- You need to have a good performance status (ECOG 0-2, meaning you are up and active most of the day).
- You must have at least one measurable or evaluable lesion on a PET/CT scan (except for certain spleen-only cases).
- Your blood counts and organ function must meet minimum levels (like adequate neutrophils, platelets, and kidney/liver function).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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