Mainstreaming Lynch syndrome diagnosis for endometrial cancer
Part of Cancer, Digestive system, Genetic & congenital, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial aims to find out if people with endometrial cancer who have a DNA repair problem called dMMR might also have Lynch syndrome. It is a simple way to screen patients during their regular cancer care without extra tests.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have endometrial cancer (stage I to IV) that tested positive for dMMR (a specific DNA repair problem).
- Your medical chart has a ‘Lynch alert’—a note from your doctor suggesting possible Lynch syndrome.
- You can understand and sign a consent form to join the study.
- You do not have serious mental or medical issues that would prevent you from giving consent.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study checks tumor tissue from colorectal cancer surgery for signs of Lynch syndrome, a genetic condition that increases cancer risk. If found, you can get genetic counseling to help you and your family.
This study looks at how the immune system interacts with the gut lining in people with Lynch syndrome and those without. It may help us better understand how Lynch syndrome affects the body.
This study is testing a new way to check for uterine cancer risk in people with Lynch syndrome. You would collect a vaginal sample yourself at home and fill out a health questionnaire, which may help catch warning signs early.
This study looks at the genetics and health of people with Lynch syndrome, a condition that raises the risk for certain cancers. Researchers want to learn more about how different genetic changes affect health over time.
This study tests whether a menstrual cup can collect cells from the uterus to detect early endometrial cancer in women with Lynch syndrome. If you have Lynch syndrome and are due for a routine biopsy, you may be able to use a menstrual cup instead.
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