Neoadjuvant treatment for BRCA-mutated HER2-negative breast cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests a combination of two oral medications (HRS-1167 and famitinib) with or without an immunotherapy drug (camrelizumab) before surgery for women with a BRCA gene mutation and HER2-negative breast cancer. It aims to see if these drugs can shrink tumors before surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be a woman between 18 and 70 years old.
- You must have a BRCA1 or BRCA2 gene mutation (proven by a blood test).
- Your breast cancer must be HER2-negative and not have spread to other organs (stage I to III, not stage IV).
- You must have a tumor that can be measured on imaging (like an MRI or CT scan).
- You must be in good general health with normal blood counts, liver, and kidney function.
- You cannot have had prior treatment with certain drugs (PARP inhibitors or VEGFR-targeted oral drugs) or a history of other cancers in the last 3 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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