Comparing two pain medicines for gynecologic cancer surgery
Treatments studied
Part of Cancer, Pain, Women’s health & pregnancy clinical trials.
This trial compares two different pain medicines (methadone given by mouth or IV vs. hydromorphone given through a spinal injection) after surgery for gynecologic cancer. It aims to find which option provides better pain relief with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for surgery through a large belly incision (laparotomy) for gynecologic cancer.
- Your hospital stay is expected to be longer than 24 hours.
- You do not take high doses of opioids (more than 20 MME/day) for chronic pain before surgery.
- Your heart, kidneys, liver, and blood clotting are in good shape (no long QT, eGFR above 30, no cirrhosis, platelets above 100, INR below 1.1).
- You are not allergic to hydromorphone, methadone, or liposomal bupivacaine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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