Efgartigimod for stiff person syndrome
Treatments studied
Part of Brain & nervous system, Immune system & allergy clinical trials.
This trial tests a medicine called efgartigimod for stiff person syndrome, a rare autoimmune condition that causes muscle stiffness and spasms. The medicine may reduce the antibodies that attack the nervous system, which could help ease symptoms and improve daily function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have stiffness in your limbs or trunk and muscle spasms that are not caused by another known condition.
- Your stiffness and spasms cause at least moderate impact on daily life (score of 2 or more on standard scales).
- You have tested positive for GAD antibodies in your blood or spinal fluid.
- You are on a stable dose of muscle relaxant or anti-spasm medication (like baclofen or a benzodiazepine) for at least 2 months.
- You do not have type 1 diabetes, active cancer, or serious infections like HIV or hepatitis B or C.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests an intravenous (IV) medication called human normal immune globulin 10% to see if it helps reduce stiffness and spasms in adults with Stiff Person Syndrome (SPS). It might improve muscle symptoms and quality of life.
This trial tests whether a drug called Vyvgart (hyaluronidase-fjjo) can help people with stiff person syndrome who still have symptoms like stiffness, painful muscle spasms, and trouble walking despite other treatments. The goal is to see if it improves these symptoms and how well it works.
This trial tests a new medicine called efgartigimod for people with Guillain-Barré syndrome (GBS), a condition where the immune system attacks the nerves. The medicine aims to reduce the immune attack and help you recover faster. It is for people who started having GBS symptoms within the last 2 weeks and have moderate to severe symptoms.
This study tests a medication called efgartigimod for people with myasthenia gravis who need regular IVIG treatments. The goal is to see if efgartigimod can help reduce the need for IVIG.
This study tests a new medicine called efgartigimod to see if it can help people with Sjogren's disease who have nerve damage (neuropathy). You may be able to join if your nerve symptoms started within the last 5 years and are getting worse.
This trial tests whether an experimental drug called efgartigimod (given as an infusion) can help people with Guillain-Barré syndrome recover faster. It is for adults who recently developed symptoms and have significant weakness that affects their walking.
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