Vyvgart for stiff person syndrome
Part of Brain & nervous system, Immune system & allergy clinical trials.
This trial tests whether a drug called Vyvgart (hyaluronidase-fjjo) can help people with stiff person syndrome who still have symptoms like stiffness, painful muscle spasms, and trouble walking despite other treatments. The goal is to see if it improves these symptoms and how well it works.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 25 and 80 years old.
- You must have a diagnosis of typical stiff person syndrome (SPS), which causes stiffness, painful muscle spasms, and problems walking.
- Your current treatments, like IVIg or rituximab, are not working well enough or have stopped being effective.
- You must test positive for GAD antibodies or glycine receptor antibodies.
- You must be able to attend study visits at the clinic.
- You must not have very mild disease (like a stiffness index less than 1) or be non-ambulatory (unable to walk), or have a type of SPS caused by cancer (paraneoplastic).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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