Clin2
NCT06530251Likely a fitRecruiting

AK112 for advanced liver cancer (HCC)

Hepatocellular Carcinoma

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests a new immunotherapy drug called AK112 for people with advanced liver cancer that hasn't spread to the brain or key blood vessels. It may be an option if you haven't had immunotherapy before and your liver is still working well.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
280 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You must be at least 18 years old and willing to sign a consent form.
  • Your liver cancer must be advanced and confirmed by biopsy or imaging.
  • You should be able to do daily activities with little or no help (ECOG score 0 or 1).
  • Your liver function must be good (Child-Pugh A).
  • If you have already received treatment, it must have been no more than 2 previous types of systemic therapy, and you must not have had immunotherapy before.
  • You must have at least one tumor that can be measured on scans and has not been treated with local therapy.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06196775Not yet recruiting· Phase 2
Second-line treatment for advanced liver cancer

This trial tests a combination of two immunotherapy drugs for people with advanced liver cancer that has progressed after first-line treatment. It aims to see if this combination can help control the cancer.

Harbin
NCT06984718Not yet recruiting· Phase 2
AK104 plus lenvatinib versus lenvatinib for advanced liver cancer after prior treatment

This trial is testing a new combination of drugs (an immunotherapy called AK104 plus a targeted therapy called lenvatinib) compared to lenvatinib alone, for people whose liver cancer has grown after they received the standard first-line treatment with atezolizumab and bevacizumab. The goal is to see if combining the two drugs can better control the cancer and help patients live longer.

NCT06201065Recruiting· Phase 3
Targeted therapy and immunotherapy for advanced liver cancer

This trial tests a combination of two drugs (lenvatinib and toripalimab, a type of immunotherapy) plus a special chemotherapy infusion directly into the liver artery for people with advanced liver cancer that has not been treated before. The goal is to see if adding the immunotherapy helps shrink tumors better than the standard combination.

Guangzhou, Guangdong
NCT05441475Enrolling by invitation· Phase 2
Trial for advanced liver cancer using ABSK-011 plus atezolizumab

This Phase 2 study tests ABSK-011 combined with either atezolizumab or the usual care in people with advanced or unresectable liver cancer. It aims to see if the treatment helps shrink tumors and control the cancer when standard options aren’t working or can’t be used.

Hubei, Shanghai Municipality
NCT06406634Recruiting· Phase 2
Cadonilimab, Lenvatinib, and HAIC for Unresectable Liver Cancer

This trial tests a combination of three treatments for advanced liver cancer that can't be removed by surgery. It uses an immunotherapy drug (cadonilimab), a targeted therapy pill (lenvatinib), and a direct chemotherapy infusion into the liver (HAIC). The goal is to see if this combo can shrink tumors and improve outcomes.

Changsha, Hunan
NCT07560488Recruiting· Phase 2
Immunotherapy and Chemotherapy Combination for Advanced Liver Cancer

This trial tests a combination of four treatments (two immunotherapy drugs, a blood-vessel-blocking drug, and chemotherapy delivered directly to the liver) to shrink unresectable (inoperable) advanced liver cancer and potentially make it removable by surgery. The goal is to help patients who have never had cancer treatment before.

Tianjin, Tianjin Municipality

Hear when a new Hepatocellular Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.