Celecoxib and metformin for familial adenomatous polyposis
Part of Cancer, Digestive system, Genetic & congenital clinical trials.
This trial tests whether a combination of two drugs, celecoxib and metformin, can prevent the growth of polyps in the colon or duodenum (the first part of the small intestine) in people with familial adenomatous polyposis (FAP). FAP is a condition that causes many polyps to form, raising the risk of cancer. If you have FAP, are between 20 and 55, and have at least 5 polyps that are 2mm or larger, this study may be for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with familial adenomatous polyposis (FAP).
- You are between 20 and 55 years old.
- You have at least 5 polyps in your colon or duodenum that are 2mm or larger.
- You have not had colon surgery in the past year and do not need surgery in the next 8 months.
- You do not have colorectal cancer or other cancers.
- You are not pregnant, breastfeeding, and do not have serious heart, stomach, or kidney problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This early-phase trial studies REC-4881 in adults with familial adenomatous polyposis (FAP), a condition that causes many colon/rectum and duodenal polyps. It aims to see whether the treatment can safely help control or shrink polyp growth in people who have had bowel surgery.
This trial tests whether a home-based exercise program can help people with familial adenomatous polyposis (FAP) who have rectal polyps. You may qualify if you have FAP, have not had your rectum removed, have at least 5 rectal polyps larger than 2 mm, and are currently inactive.
This trial looks at how many colon polyps progress toward cancer in people with familial adenomatous polyposis (FAP). It may help doctors better predict risk and guide safer monitoring or treatment for you.
This trial tests whether taking a supplement called beta-hydroxybutyrate (BHB) can help prevent polyps in people with familial adenomatous polyposis (FAP), a condition that causes many polyps in the colon. The study has two parts: one for people who have already had colon surgery, and another for those who still have their colon.
This trial tests the drug rapamycin to see if it can help prevent polyps from growing in children aged 12 to 17 with familial adenomatous polyposis (FAP). The goal is to find out if it can reduce the number or size of polyps, which may lower the risk of needing surgery.
This trial studies a tailored plan for surveillance (check-ups) and interventions to find and remove new growths early in people with familial adenomatous polyposis (FAP) after bowel surgery. It may help lower the chance of cancer by closely monitoring and treating polyps when they appear.
Hear when a new Familial Adenomatous Polyposis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.