Clin2
NCT06546475Possibly a fitNot yet recruiting

Tapering antipsychotics with N-acetylcysteine for stable schizophrenia

Psychosis

Treatments studied

Part of Mental health clinical trials.

This study is testing whether adding a supplement called N-acetylcysteine (a type of antioxidant) can help people who are stable on antipsychotic medication safely reduce their medication dose. It aims to see if this approach helps maintain wellness while lowering medication side effects.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
20 people
Ages
18 years to 60 years
Study type
Interventional

Who can take part

  • You are between 18 and 60 years old.
  • You have been diagnosed with schizophrenia or a related thought disorder.
  • Your symptoms (like hallucinations or strange thoughts) have been mild and stable for at least 3 months.
  • You have been on the same dose of your antipsychotic medication for at least 3 months.
  • You have not been hospitalized for psychiatric reasons in the past 6 months.
  • You are not currently pregnant or breastfeeding (if applicable).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05142735Recruiting
NAC for early psychosis risk symptoms

This trial studies whether NAC (a nutrient-like supplement) can reduce symptoms in people who are at high risk for developing psychosis. It may help by testing a safer, non-standard treatment approach for early warning signs.

Toronto, Ontario
NCT04959201Recruiting· Phase 2
NMDA and antioxidant add-on to treat schizophrenia symptoms

This Phase 2 trial tests whether adding an “NMDA-enhancing” treatment plus an antioxidant can improve ongoing schizophrenia symptoms over 12 weeks. It’s meant for people who still have symptoms even though their usual antipsychotic dose has been stable for at least 3 months.

Taichung
NCT05408247Recruiting· Phase 4
N-acetylcysteine to help people cut back on alcohol

This trial tests whether N-acetylcysteine (a supplement-like medicine) can help people with alcohol use disorder reduce or stop drinking. You may be randomly assigned to receive N-acetylcysteine or a comparison treatment, and you’ll complete interviews during the study.

Sydney, New South Wales
NCT06021197Recruiting· Phase 2
NMDA-enhancing treatment for cognitive symptoms in schizophrenia

This study tests a new treatment that may help with thinking and memory problems in people with schizophrenia. It is for people whose schizophrenia symptoms are stable and who are already on a steady medication.

Taichung
NCT05494398Enrolling by invitation· Phase 2/Phase 3
Testing N-acetylcysteine for autism symptoms

This study looks at whether N-acetylcysteine (NAC), a supplement/medication, can help autism-related symptoms by trying to target brain chemistry. You may be able to join if you previously took part in a related NAC study and can keep your usual medications steady.

Stanford, California
NCT04381897Not yet recruiting· Phase 2
NAC treatment for repetitive behaviors in Cornelia de Lange syndrome

This study tests whether N-acetylcysteine (a supplement) can reduce repetitive or self-injurious behaviors in people with Cornelia de Lange syndrome. It involves 4 hospital visits over 18 weeks.

Baltimore, Maryland

Hear when a new Psychosis trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.