Treatment
N-Acetylcysteine clinical trials
We’re tracking 27 recruiting studies that include N-Acetylcysteine, each written for real people, not researchers, below.
Recruiting studies
- NCT03652753RecruitingPhase 4
NAC injection during staged surgery for pilon fractures
This study looks at whether injecting N-acetylcysteine (NAC) into the joint during staged surgery can improve care for certain high-energy pilon fractures. It may help support healing where the joint is involved.
Columbia, MissouriAges 18 years+ - NCT06811675RecruitingPhase 4
Preventing brain damage after carbon monoxide poisoning
This trial tests if combining two common medicines, dexamethasone and N-acetylcysteine, can help prevent long-term brain problems in people who have been poisoned by carbon monoxide.
TaichungAges 18 years+ - NCT04278898RecruitingPhase 2
N-acetylcysteine to reduce repetitive behaviors in children with autism
This Phase 2 study tests whether a single dose of N-acetylcysteine can improve “restricted and repetitive behaviors” in children with autism. It’s meant for kids who are stable and still in early puberty stages.
Stanford, CaliforniaAges 3–12 - NCT05123365RecruitingPhase 1/Phase 2
Testing a dose of N-acetylcysteine for certain blood cancers
This Phase 1/2 study tests what dose of N-acetylcysteine (NAC) is safe and potentially helpful for people with essential thrombocythemia, polycythemia vera, or myelofibrosis. It focuses on people who still have symptoms and meet blood and health requirements so researchers can monitor side effects and symptom changes.
Irvine, CaliforniaAges 18 years+ - NCT05241262RecruitingPhase 1
N-acetylcysteine for people with m.3243A>G and low brain glutathione
This trial tests whether the supplement N-acetylcysteine (NAC) can help people who have the m.3243A>G mitochondrial genetic change and low levels of a brain chemical called glutathione. The study aims to see if raising glutathione in the brain is safe and potentially beneficial for these patients.
New York, New YorkAges 18–80 - NCT05294744Recruiting
N-acetylcysteine plus usual care for severe alcoholic hepatitis
This study tests whether adding N-acetylcysteine to standard treatment helps people with severe alcoholic hepatitis. It may improve liver outcomes, especially for those with a high Maddrey score.
Vitoria-Gasteiz, ÁlavaAges 18–75 - NCT05664789RecruitingPhase 2/Phase 3
N-acetylcysteine for autism behaviors in children
This trial studies whether N-acetylcysteine, a medicine taken by mouth, can improve autism-related restricted and repetitive behaviors in children. It looks at children who are showing at least moderate severity in these behaviors and may involve brain testing for safety reasons.
Palo Alto, CaliforniaAges 3–12 - NCT06484530RecruitingPhase 4
Gene-guided NAC to prevent TB drug liver injury
This trial tests whether a medicine called N-acetylcysteine (NAC) can help prevent liver damage caused by standard TB drugs. If you have a higher risk of liver injury based on your genes, you may be given NAC along with your TB treatment.
Bangkok Noi, BangkokAges 18–80 - NCT06727422RecruitingPhase 2
Rifaximin plus NAC for IBS with diarrhea
This trial tests whether a combination of two medications—rifaximin (a gut antibiotic) and NAC (a supplement that helps break down mucus)—can reduce belly pain and diarrhea in people with IBS whose symptoms are not well controlled. It may be an option if other treatments haven't worked well enough.
Los Angeles, CaliforniaAges 18 years+ - NCT06956482RecruitingPhase 3
Longer steroids or N-acetylcysteine for severe alcoholic hepatitis
This trial tests whether giving corticosteroids for a longer time, or adding a medicine called N-acetylcysteine, can help people with severe alcoholic hepatitis. It is for patients who have been drinking heavily and recently developed jaundice.
LilleAges 18–75 - NCT07245095RecruitingPhase 2
Pre-medication for better views during upper endoscopy
This trial tests whether taking two medicines (N-acetylcysteine and simethicone) before an upper endoscopy helps the doctor see the stomach lining more clearly. It may be an option for people having their first endoscopy, without active bleeding.
Mexicali, Estado de Baja CaliforniaAges 18–99 - NCT05494398Enrolling by invitationPhase 2/Phase 3
Testing N-acetylcysteine for autism symptoms
This study looks at whether N-acetylcysteine (NAC), a supplement/medication, can help autism-related symptoms by trying to target brain chemistry. You may be able to join if you previously took part in a related NAC study and can keep your usual medications steady.
Stanford, CaliforniaAges 3–13 - NCT07765823Recruiting
N-acetylcysteine for liver failure not caused by acetaminophen
This trial tests whether the drug N-acetylcysteine (NAC) can help people with sudden liver failure that is not caused by acetaminophen (like Tylenol). If you qualify, you may receive NAC, which might help your liver recover.
Lahore, Punjab ProvinceAges 18–60 - NCT07414212RecruitingPhase 1/Phase 2
Testing EH-301 and NAC with Riluzole for ALS
This trial tests whether adding two supplements (EH-301 and N-acetylcysteine) to the standard ALS medicine Riluzole can help slow the disease. It is for people diagnosed with ALS within the last 18 months who still have good breathing and daily function.
San Sebastián, GuipuzcoaAges 18–75 - NCT05408247RecruitingPhase 4
N-acetylcysteine to help people cut back on alcohol
This trial tests whether N-acetylcysteine (a supplement-like medicine) can help people with alcohol use disorder reduce or stop drinking. You may be randomly assigned to receive N-acetylcysteine or a comparison treatment, and you’ll complete interviews during the study.
Sydney, New South WalesAges 18–70 - NCT06039566RecruitingPhase 3
NAC vs placebo for pain after hysterectomy
This trial tests if a medicine called N-acetylcysteine (NAC) can reduce the need for strong pain pills after hysterectomy surgery. If you are having a laparoscopic or robotic hysterectomy, this study may help you recover with less opioid pain medicine.
Charleston, South CarolinaAges 18 years+ - NCT07464886RecruitingPhase 3
NAC and mindfulness therapy for depression in youth
This study tests whether a supplement called N-acetylcysteine (NAC) combined with a type of therapy called Mindfulness-Based Cognitive Therapy (MBCT) can help improve depression in teenagers and young adults. It looks at how these treatments affect brain chemicals and may reduce symptoms.
Cincinnati, OhioAges 15–24 - NCT06165068RecruitingPhase 3
Antiplatelet and antioxidant drugs for dry AMD with drusen
This study tests whether antiplatelet drugs (like aspirin) and antioxidants can slow the growth of drusen (yellow deposits) in dry age-related macular degeneration (AMD). It may help prevent the disease from worsening.
Bangkok, DusitAges 50–85 - NCT04460521RecruitingPhase 4
NAC pills and night splints for carpal tunnel without surgery
This trial tests whether N-acetylcysteine (NAC) along with wearing a night wrist splint can improve symptoms of mild to moderate carpal tunnel syndrome. It’s designed for people who want a non-surgical option.
Halifax, Nova ScotiaAges 18 years+ - NCT04740580RecruitingEarly Phase 1
Test glutathione for brain inflammation in Alzheimer’s
This early-stage study tests whether taking glutathione can affect brain “inflammation” and metabolism in people with Alzheimer’s disease. You might benefit from a new treatment approach, while helping researchers understand what works best for early Alzheimer’s-related brain changes.
Houston, TexasAges 55–85 - NCT07117630RecruitingPhase 2
A new drug combo for advanced breast cancer after standard treatment
This trial tests a new drug combination for women with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after standard treatments like CDK4/6 inhibitors and hormone therapy. It aims to see if the combination can help when other options have stopped working.
ShanghaiAges 18 years+ - NCT05142735Recruiting
NAC for early psychosis risk symptoms
This trial studies whether NAC (a nutrient-like supplement) can reduce symptoms in people who are at high risk for developing psychosis. It may help by testing a safer, non-standard treatment approach for early warning signs.
Toronto, OntarioAges 16–35 - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06354712RecruitingPhase 2
Can N-acetylcysteine prevent mouth sores during radiation?
This study tests whether a medicine called N-acetylcysteine (NAC) can prevent mouth sores caused by radiation therapy for head and neck cancer. If you are starting radiation, this trial may help protect your mouth from painful side effects.
Al MansurahAges 18–80
What N-Acetylcysteine is being studied for
Conditions with recruiting N-Acetylcysteine studies.
Common questions
- Are there clinical trials studying N-Acetylcysteine?
- Yes. Clin2 currently lists 27 recruiting studies that include N-Acetylcysteine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a N-Acetylcysteine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is N-Acetylcysteine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether N-Acetylcysteine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.