Reducing Anticholinergic Medications in Schizophrenia
Part of Mental health clinical trials.
This trial is testing whether it is safe to slowly reduce or stop anticholinergic medications (benztropine or trihexyphenidyl) in people with schizophrenia. It aims to see if stopping these drugs can help with thinking and memory without causing worsening movement problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a diagnosis of schizophrenia, schizoaffective disorder, or a related psychotic disorder, confirmed by a doctor.
- You must be taking benztropine or trihexyphenidyl (medications for antipsychotic side effects) for at least 6 months.
- You must be between 35 and 70 years old.
- You should not have serious side effects from the anticholinergic medication, like fever or blurry vision.
- You cannot have a neurological condition like Parkinson's disease, dementia, multiple sclerosis, lupus, or a history of traumatic brain injury.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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