Brain imaging study of antipsychotic effects in schizophrenia
Part of Mental health clinical trials.
This study uses PET and MRI scans to see how antipsychotic medications affect the brain's dopamine system in people with schizophrenia, compared to healthy individuals. It may help understand if these medications cause changes that lead to worsening symptoms over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 65 years old.
- You must be able to understand and sign the consent form.
- For patients: You must have a diagnosis of schizophrenia. If you are a first-episode patient, you must not have taken antipsychotic drugs before. If you have been treated before, you must have been on a stable dose of aripiprazole, quetiapine, or risperidone for at least one year, and be able to take a short break from your medication.
- For healthy volunteers: You must have no current or past psychiatric disorders, and you must not be taking any regular medications.
- You must not be allergic to apomorphine or similar drugs.
- You must not have participated in other clinical trials in the last 6 months, or been exposed to radiation in research studies in the last 5 years.
- You must not have active substance abuse or addiction (except nicotine).
- If you are female, you must not be pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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