Testing Two Drugs for Lupus and Rheumatoid Arthritis
Treatments studied
Part of Bones, joints & muscles, Immune system & allergy, Skin clinical trials.
This trial tests two study drugs, inebilizumab and blinatumomab, for people with lupus (SLE) or rheumatoid arthritis (RA) that hasn't gotten better with standard treatments. It focuses on those with active disease, especially lupus-related kidney problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a diagnosis of moderate-to-severe lupus (SLE) or rheumatoid arthritis (RA) that hasn't responded well to standard treatments.
- If you have lupus kidney disease (lupus nephritis), you need a biopsy that shows a specific type (class III, IV, or V) and have tried at least one or two other therapies without success.
- If you have rheumatoid arthritis, it must be active and not responding to at least one conventional DMARD and two biologic or targeted drugs.
- You cannot have taken certain advanced immune cell therapies (like CAR T or T-cell engagers) before.
- You need to be on stable doses of your current lupus or arthritis medications for a few weeks before starting the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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