Study of AZD5492 for lupus, myositis, or rheumatoid arthritis
Part of Bones, joints & muscles, Brain & nervous system, Immune system & allergy, Skin clinical trials.
This trial tests an investigational drug called AZD5492 for people with active lupus, inflammatory myositis, or rheumatoid arthritis who haven't responded well to other treatments. It aims to see if the drug is safe and how it works in the body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have lupus, myositis (excluding IBM and cancer-related), or rheumatoid arthritis with moderate-to-severe disease activity.
- You have tried and not responded well or couldn't tolerate at least 2 to 3 standard treatments for your condition (depending on the disease).
- For lupus: you test positive for ANAs, anti-dsDNA, or anti-Sm antibodies, and have a SLEDAI-2K score of 4 or higher.
- For myositis: you have positive autoantibodies, and muscle weakness or skin involvement, and active disease shown by muscle enzymes or imaging.
- For rheumatoid arthritis: you have positive RF or ACPA antibodies, at least 6 tender and 6 swollen joints, and a DAS28-CRP score above 3.2.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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