Can colchicine reduce knee or hip replacement?
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study tests whether a low-dose medicine called colchicine can lower the chance that people with knee or hip arthritis will need a joint replacement. If you have arthritis in your knee or hip and are not already scheduled for surgery, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been told by a doctor that you have arthritis (osteoarthritis) in your knee or hip.
- You are between 45 and 80 years old.
- You have either evidence of moderate to severe arthritis on an X-ray (Kellgren-Lawrence score 2 or higher), or you have had knee/hip pain for at least 2 years.
- You are not currently waiting for a hip or knee replacement surgery.
- You do not have severe kidney or liver problems, and you are not taking certain medicines (like some antibiotics or heart drugs) that could interfere with the study drug.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if taking colchicine around the time of knee replacement surgery can improve recovery. Colchicine is a medicine that reduces inflammation, which might help with pain and healing after surgery.
This trial tests if a low dose of colchicine, a medicine that reduces inflammation, can help improve blood vessel and bone health in people with moderate chronic kidney disease.
This trial tests whether taking colchicine around the time of surgery can reduce bad events after surgery in people at higher heart risk. It focuses on helping prevent complications related to inflammation after an operation.
This trial tests whether low-dose colchicine can reduce “residual” risk—future heart and blood-vessel problems—in people with peripheral artery disease (PAD). It targets PAD symptoms and complications like poor blood flow in the legs, even after certain procedures.
This trial tests if a low dose of colchicine can help people who cannot take statins due to side effects. It aims to see if colchicine is safe and effective for lowering inflammation and improving cholesterol management.
This trial tests whether a low dose of the anti-inflammatory drug colchicine can help people who have recently had a heart attack or unstable angina. It aims to see if colchicine reduces the risk of future heart problems.
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