Can colchicine reduce knee or hip replacement?
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study tests whether a low-dose medicine called colchicine can lower the chance that people with knee or hip arthritis will need a joint replacement. If you have arthritis in your knee or hip and are not already scheduled for surgery, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been told by a doctor that you have arthritis (osteoarthritis) in your knee or hip.
- You are between 45 and 80 years old.
- You have either evidence of moderate to severe arthritis on an X-ray (Kellgren-Lawrence score 2 or higher), or you have had knee/hip pain for at least 2 years.
- You are not currently waiting for a hip or knee replacement surgery.
- You do not have severe kidney or liver problems, and you are not taking certain medicines (like some antibiotics or heart drugs) that could interfere with the study drug.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests whether a low dose of the anti-inflammatory drug colchicine can help people who have recently had a heart attack or unstable angina. It aims to see if colchicine reduces the risk of future heart problems.
This trial tests whether colchicine, a drug that reduces inflammation, can help prevent further heart problems or strokes in people with moderate chronic kidney disease. You may be eligible if you have kidney disease and have had a heart attack, stroke, or related event in the past.
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