Colchicine before surgery to lower heart and inflammation complications
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests whether taking colchicine around the time of surgery can reduce bad events after surgery in people at higher heart risk. It focuses on helping prevent complications related to inflammation after an operation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a past heart procedure (stent/PCI or bypass/CABG) OR you have significant blocked heart arteries seen on a recent angiogram
- You are scheduled for an intermediate- or high-risk operation (such as abdominal/intraperitoneal, neurosurgery, major blood vessel surgery, or chest/thoracic surgery)
- If your surgery is planned to be only laparoscopic (small-incision) or endovascular (through blood vessels), you must have at least one specific heart risk history (like prior heart attack, heart failure, stroke/TIA, insulin use, or poor kidney function)
- You have NOT taken colchicine in the last month and you have no known colchicine intolerance
- You do not have severe kidney failure (very low kidney filtering or on dialysis), serious liver disease, or active infection at the time of enrollment
- You are able to consent and are not pregnant or breastfeeding, and you are not starting a competing study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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