Colchicine for pain after knee replacement surgery
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether taking a medicine called colchicine (a pill that helps reduce inflammation) before and after knee replacement surgery helps lessen pain and improve recovery. It compares standard care with and without colchicine, which may help reduce swelling and pain after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and are planning to have a total knee replacement (knee arthroplasty) for knee arthritis.
- Your kidneys are working well (a blood test called GFR should be 60 or higher).
- Your liver is working well (no severe liver disease or cirrhosis).
- You have not had an allergic reaction to colchicine before.
- You do not take strong painkillers (opioids) on a regular basis (filled a prescription more than twice in the past 6 months).
- You are not pregnant or planning to become pregnant during the first few days after surgery.
- You are not taking certain medicines (like some antifungals, antibiotics, heart medicines, or cholesterol drugs) that could interact badly with colchicine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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