Immunotherapy to save the stomach or colon from surgery
Part of Cancer, Digestive system clinical trials.
This trial tests whether using immune checkpoint inhibitors alone (like checkpoint blockade drugs) can help people with certain gastric or colon cancers avoid surgery. It's for patients whose tumors have a specific genetic feature called dMMR/MSI-H and haven't spread to other parts of the body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have been diagnosed with stomach or colon cancer that hasn't spread to other organs.
- Your tumor must have a specific genetic marker called dMMR or MSI-H (a protein or gene test shows this).
- You must be healthy enough to carry out daily activities (ECOG score 0-2).
- You must be 18 years or older.
- You must not have had prior treatment with a certain type of immunotherapy (CTLA-4 blockers).
- You must not have active autoimmune diseases or serious uncontrolled health problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether using a simple blood test (ctDNA) can help guide treatment with immunotherapy drugs (PD-1 inhibitors) for people with a specific type of colon cancer (MSI-high/dMMR). The goal is to see if this approach can improve outcomes and reduce side effects compared to standard care.
This trial tests whether giving a combination of two immunotherapy drugs before surgery can help shrink stomach cancer and reduce the chance of it coming back. It is for people whose tumors have a specific genetic feature called MSI-H or dMMR, which often responds well to immunotherapy.
This study tests a lower dose of immunotherapy in patients with colorectal or stomach cancer that has spread or cannot be removed by surgery. The cancer must have a specific genetic feature (MSI/dMMR). The goal is to see if this approach works well with fewer side effects.
This trial tests whether giving the immunotherapy drug sintilimab along with low-dose radiation before surgery can help shrink stomach cancer that has a specific DNA repair defect (dMMR/MSI-H). The goal is to make surgery more effective and improve outcomes.
This trial tests whether giving the immunotherapy drug pembrolizumab before surgery can shrink or eliminate colon tumors in people with dMMR/MSI-high cancer, possibly allowing some to avoid surgery. It is for patients whose cancer has not spread.
This trial tests how well immunotherapy (drugs that boost your immune system to fight cancer) works before surgery for stomach cancer that has a specific genetic marker (dMMR or MSI-H). It aims to find factors that predict response, which may lead to more personalized and effective treatment.
Hear when a new Gastric Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.