Botulinum toxin plus daily tadalafil for erectile dysfunction
Treatments studied
Part of Hormones & metabolism, Kidney & urinary clinical trials.
This trial tests if combining two treatments—a botulinum toxin injection and a daily oral medication (tadalafil)—can help men with diabetes-related erectile dysfunction who haven't responded well to standard pills. The goal is to see if this combination improves erections better than either treatment alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a man with diabetes and erectile dysfunction caused by blood vessel problems.
- You have been in a stable relationship (married) for at least some time.
- Standard erectile dysfunction pills (like Viagra or Cialis) have not worked well for you, even at the highest dose, for at least 3 months.
- You have had a penile ultrasound (Penile Duplex) that confirms the problem is due to blood vessel issues.
- You have tried a medication called PGE-1 as an injection, and your erection hardness score after that was 3 or less (on a scale of 1 to 4).
- You do not have serious heart problems, unstable mental health conditions, penis shape abnormalities, or a history of spinal or pelvic surgery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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