Testing inclisiran for carotid artery plaques
Treatments studied
Part of Hormones & metabolism clinical trials.
This study tests a new medicine called inclisiran (a small interfering RNA) to see if it can shrink or stabilize fatty plaques in neck arteries. You may qualify if you have carotid plaques and high LDL cholesterol despite statin use or if you haven't taken statins.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Have fatty deposits (plaques) in your neck arteries seen on an ultrasound.
- Be between 18 and 75 years old.
- Have high LDL cholesterol that isn't controlled enough—either without taking statins or after 4 weeks on statins.
- Not have had a hemorrhagic stroke or certain heart procedures.
- Not be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding inclisiran to your current statin can reduce dangerous, rupture-prone plaque in your heart arteries. It may help if you have a moderate blockage with thin-cap plaque and your LDL cholesterol stays high despite statins.
This study tests a new injectable medicine called inclisiran for people who are already on many medications and have high cholesterol. It is designed for those who cannot lower their cholesterol enough with statins, especially if they have diabetes or other heart risks.
This trial tests a new version of inclisiran, a cholesterol-lowering medicine, to see if it is safe and works well. The study compares it to the current version. You may qualify if you have moderately high cholesterol but have never taken cholesterol medications.
This study tests whether a twice-yearly injection called inclisiran can prevent heart attacks, strokes, or leg complications in people who recently had a procedure to open a blocked artery. You may be eligible if you had a heart or leg artery procedure within the last two weeks.
This study tests two newer cholesterol-lowering medications (inclisiran and alirocumab) together in people who've had heart problems or strokes and cannot tolerate standard cholesterol drugs. The goal is to see if this combination safely lowers cholesterol further and reduces future cardiovascular events.
This study tests if starting inclisiran soon after a heart attack helps lower cholesterol further in patients already on statins. The goal is to see if early treatment can reduce future heart risks.
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