Brain stimulation for Alzheimer's disease
Part of Brain & nervous system, Mental health clinical trials.
This study tests whether a new type of brain stimulation (called repetitive transcranial magnetic stimulation, or rTMS) with a larger coil can improve memory and thinking in people with mild to moderate Alzheimer's disease. It involves multiple sessions of rTMS and MRI scans.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a caregiver or study partner who can attend all visits.
- You must have a confirmed diagnosis of mild to moderate Alzheimer's disease based on biomarkers (e.g., amyloid PET or CSF test).
- You must be between 55 and 100 years old.
- You must score between 12 and 25 on the Montreal Cognitive Assessment (MOCA).
- You must score below 6 on the Geriatric Depression Scale (GDS).
- You must not have had a stroke, traumatic brain injury, or other major neurological disorder.
- You must not have a history of seizures or a first-degree relative with seizures.
- You must not have had prior TMS treatment (for the randomized phase).
- You must not be currently taking certain medications (e.g., anticholinergics, sedating antihistamines, benzodiazepines, opioids, antiepileptics, antipsychotics) unless approved by the study team.
- You must not have started treatment with lecanemab, donanemab, or other monoclonal antibodies for Alzheimer's within the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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