Extended antiviral combo for persistent COVID-19 in weakened immunity
Treatments studied
Part of Infections, Lungs & breathing clinical trials.
This trial tests a longer course of remdesivir plus Paxlovid (nirmatrelvir/ritonavir) for immunocompromised people with persistent COVID-19. It aims to see if combining these two antiviral medicines can help clear the virus more effectively.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You have received a 'B-cell depleting' immune therapy (like rituximab) or the chemo drug bendamustine in the last 6 months
- You have a lab-confirmed COVID-19 infection and symptoms started within the last 3 days
- You are not on a breathing machine (ventilator) and have a moderate COVID severity (NIAID score 0-5)
- You haven't taken any other anti-COVID drug in the last 2 weeks (except remdesivir or Paxlovid started within 24 hours)
- You do not have severe kidney (eGFR < 30) or liver (Child-Pugh C) problems, or other serious health issues that would make the study unsafe for you
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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