Clinical trials
COVID-19 clinical trials
Below are recruiting covid-19 clinical trials, each written for real people, not researchers. We’re tracking 304 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05890612Recruiting
Study of Paxlovid safety and effectiveness in high-risk COVID-19
This study observes people at higher risk for severe COVID-19 who take Paxlovid, to better understand how well it works and how safe it is in real-world use. It may help doctors confirm the best way to use Paxlovid and spot any side effects.
SeoulAges 19 years+ - NCT05126589Recruiting
COVID-19 respiratory sample testing using virus genetic clues
This study looks at respiratory samples from adults after COVID-19 to better understand what viruses may be present and how they change over time. If you live in Hong Kong and can consent, you may be able to help researchers learn from your samples and symptoms.
Hong Kong, Hong KongAges 18 years+ - NCT06821100RecruitingPhase 1
Thymalfasin to Boost COVID-19 Vaccine Response in Older Adults
This trial tests whether a drug called thymalfasin (thymosin alpha 1) can help older adults (65+) get a stronger immune response from their COVID-19 booster shot. It may be especially helpful for those whose immune systems have weakened with age.
Houston, TexasAges 65–100 - NCT05787327RecruitingPhase 2
Chinese Herbal Medicine for COVID-19
This trial tests a combination of two traditional Chinese herbal formulas (Yinqiaosan and Maxingganshitang) to see if they can help people with mild to moderate COVID-19 recover faster. It's for adults who have had symptoms for no more than 3 days and have been diagnosed with a specific Chinese medicine pattern.
Hong KongAges 18–65 - NCT06086379Enrolling by invitation
Cognitive rehab therapy for COVID-related thinking problems in Veterans
This study tests a cognitive rehabilitation therapy designed to help Veterans who have memory and thinking problems after COVID-19. It aims to improve daily mental function and quality of life.
San Diego, CaliforniaAges 18 years+ - NCT03808922RecruitingPhase 3
DAS181 treatment for COVID-19 lung infection in immune-compromised adults
This Phase 3 trial tests DAS181 to treat lower lung (chest) viral infections in people with weakened immune systems, including a COVID-19 subgroup. It may help by targeting certain viruses in the lungs, but joining depends on your oxygen needs, recent diagnosis, and other safety factors.
Duarte, CaliforniaAges Any age - NCT04359836Recruiting
Study of gut bacteria in early COVID-19
This trial studies how gut bacteria (“gut flora”) may affect COVID-19 after a recent infection. If you test positive for COVID-19 soon enough, the study may help researchers understand why some people get better faster or have different symptoms.
Ventura, CaliforniaAges 18 years+ - NCT04363541Recruiting
Thermotherapy for mild to moderate COVID-19 symptoms
This trial studies whether local heat treatment (thermotherapy) can improve outcomes for people with mild to moderate COVID-19. It’s designed for people early in their illness (within 5 days) who still have good oxygen levels.
Guadalajara, JaliscoAges 18 years+ - NCT04367857Recruiting
Study of COVID antibody levels in healthcare workers
This study measures how many healthcare workers have COVID antibodies (proof of past infection or immune response). Results may help estimate how widespread COVID exposure has been among hospital staff.
New York, New YorkAges 18 years+ - NCT04404062Recruiting
COVID-19 test study using blood and swab samples
This study checks whether different COVID-19 tests (a blood test and swab-based tests) can detect or confirm infection. If you join, you’ll follow the study steps so researchers can compare results and improve testing.
London, LondonAges 5–70 - NCT04442191RecruitingPhase 2
Convalescent plasma for hospitalized COVID-19 patients over 40
This trial tests whether donated “recovered patient” plasma (antibodies from people who had COVID-19) can improve outcomes for people hospitalized with COVID-19. It focuses on patients early in their illness who need a small amount of oxygen.
Chicago, IllinoisAges 40 years+ - NCT05041907RecruitingPhase 2
Testing an antiviral’s effects in early COVID-19
This trial looks at how well an antiviral works in the body when started early in people with COVID-19 symptoms. You may be able to join if you’re an otherwise healthy adult with confirmed infection and symptoms for less than 4 days.
Minas GeraisAges 18–60 - NCT05164744Recruiting
MRI study of heart tissue changes after COVID-19
This study uses a heart MRI to look for leftover (healing) changes in heart tissue after COVID-19. It may help researchers better understand what ongoing heart effects can happen after infection.
Brooklyn, New YorkAges 18 years+ - NCT05191381Recruiting
Immune treatment using exosome therapy for severe COVID-19
This trial tests whether immune-supporting treatment made from exosomes can help people with critically severe COVID-19 and lung damage. If you qualify, you may receive this therapy as part of the study to see if it improves outcomes.
UlmAges 18–90 - NCT05197621Recruiting
Study how COVID-19 affects pregnancy and newborn outcomes
This study looks at how COVID-19 and COVID vaccination during pregnancy may affect mothers and newborns. Your team will collect health information around delivery to understand what outcomes are most common.
Baltimore, MarylandAges 14–55 - NCT05218083Recruiting
Mobile rehab program with interval exercise after COVID-19
This trial tests a coach-supported, phone-based rehabilitation program that includes high-intensity interval-style exercise for people recovering from COVID-19 after a hospital stay. It may help improve breathing, strength, and walking by providing structured exercise at home.
Birmingham, AlabamaAges 18 years+ - NCT05218356RecruitingPhase 2
Codivir trial for hospitalized moderate COVID-19
This trial tests whether Codivir can help people hospitalized with moderate COVID-19 recover better than a placebo (inactive pill). It will compare outcomes while participants receive standard hospital care.
Paulo Prata, Barretos/SP/BRAAges 18–75 - NCT05268523Recruiting
Online self-management program for long COVID symptoms
This trial tests an online self-management program to help people cope with long COVID symptoms in everyday life. It may help if you’re struggling with ongoing symptoms like mood changes, memory/thinking issues, or physical problems after COVID.
Toronto, OntarioAges 18 years+ - NCT05387369Recruiting
Real-world study of Paxlovid for hospitalized COVID-19 patients
This study checks how Paxlovid works in everyday care for people who are hospitalized with confirmed COVID-19. If you have a positive COVID-19 test and mild to moderate symptoms, this trial may help doctors understand how well the treatment performs outside of tightly controlled settings.
ShanghaiAges 12 years+ - NCT05415267RecruitingPhase 3
Boosting COVID protection during long-term immune suppression
This study looks at how well a COVID-19 booster works in adults who need long-term medicines that lower immune response. It aims to see whether immunosuppressed people benefit from booster vaccination safely.
Blacktown, New South WalesAges 18 years+ - NCT05504057Recruiting
Testing antihistamines and amantadine for COVID-19
This study looks at how ongoing antihistamines or amantadine treatment affects the course of COVID-19. If you already take one of these medicines regularly, the study may help understand whether it offers any benefit.
Terrassa, BarcelonaAges Any age - NCT05531773Recruiting
Study for ongoing symptoms after COVID-19
This trial studies people with mild to moderate COVID-19 symptoms to better understand and help “post-COVID” condition (ongoing effects after infection). You may be eligible if you’re an adult with a recent confirmed COVID-19 test and you agreed to take part.
DüsseldorfAges 18 years+ - NCT05553743Recruiting
Study of donated breast milk and how it affects child health
This study looks at breast milk donated for research and how it may relate to infant and child health. If you’re an adult who is breastfeeding and can donate extra milk, you may be able to participate.
San Diego, CaliforniaAges 18 years+ - NCT05562505Recruiting
Using ECMO to help you breathe, sit up, and come off a ventilator
This trial tests whether a heart-lung machine called venovenous ECMO can help people with severe breathing failure get less sedated, get extubated (have the breathing tube removed), and start moving. It’s for certain adults who are on a ventilator for a short time and have specific oxygenation problems.
Darlinghurst, New South WalesAges 18–65
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COVID-19 trials by city
Studies with a site in or near these metro areas.
COVID-19 trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for covid-19?
- Yes. Clin2 currently lists 304 recruiting covid-19 studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a covid-19 trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a covid-19 trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.