Comparing two pain medicines for pancreatitis prevention after ERCP
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether parecoxib or indomethacin works better at preventing pancreatitis, a common complication after a procedure called ERCP. Participants will receive one of the two medicines before the procedure, and the study will track which one is safer and more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You are scheduled to have an ERCP for a bile duct problem, such as stones, narrowing, infection, or jaundice.
- You have not had the small opening between your bile duct and intestine removed (papillectomy) or cut (sphincterotomy) before.
- You are not currently taking aspirin-like pain relievers (NSAIDs) and have not used them in the past week.
- You do not have active pancreatitis, stomach or intestinal bleeding, or certain liver, kidney, or heart conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if applying cold therapy or giving an NSAID (anti-inflammatory medication) before an ERCP can prevent pancreatitis, a common complication. It is for adults having their first ERCP.
This study compares two common NSAID medications (indomethacin and diclofenac) given before an ERCP procedure to see if one is better at preventing pancreatitis, a common complication. If you are having an ERCP and meet the health criteria, you may be able to join.
This trial is testing whether higher doses of a common anti-inflammatory drug (indomethacin) given as a suppository can better prevent pancreatitis after an ERCP procedure in people who are at high risk for this complication.
This study compares indomethacin (an anti-inflammatory medicine) against using a temporary pancreatic stent to prevent pancreatitis after an ERCP procedure. It may help you lower the chance of painful inflammation of the pancreas after ERCP.
This Phase 3 study tests whether putting an anti-inflammatory medicine into the rectum (indomethacin) plus taking an immune-suppressing pill (tacrolimus) works better than using the two medicines in a different combination to prevent pancreatitis after an ERCP procedure. If you qualify, you may be assigned to one of the treatment options to lower your risk of post-ERCP pancreas inflammation.
This study tests whether a rectal suppository of indomethacin (a type of anti-inflammatory) can help prevent complications during a bile duct procedure called ERCP. It's for people who have already had a prior bile duct cut.
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