Medicines to prevent pancreas swelling after ERCP
Treatments studied
Part of Digestive system clinical trials.
This Phase 3 study tests whether putting an anti-inflammatory medicine into the rectum (indomethacin) plus taking an immune-suppressing pill (tacrolimus) works better than using the two medicines in a different combination to prevent pancreatitis after an ERCP procedure. If you qualify, you may be assigned to one of the treatment options to lower your risk of post-ERCP pancreas inflammation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and having an ERCP at one of the participating centers
- You are able and willing to sign informed consent
- You are not pregnant and you are not breastfeeding
- You do NOT have standard reasons you cannot take indomethacin (an NSAID) or tacrolimus (a tacrolimus medicine)
- You are not using tacrolimus or other immune-modifying medicines right now
- You do not have serious kidney problems (very low kidney function or recent kidney injury) and you still have a rectum
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether using rectal NSAIDs (a type of painkiller) with or without a small tube (stent) in the pancreas can prevent pancreatitis after ERCP. It's for people who are at higher risk for this complication.
This trial tests if giving fluids before an ERCP procedure can lower the risk of developing pancreatitis (inflammation of the pancreas). It may help people who have not had this procedure before.
This trial tests whether a single dose of tacrolimus, a medicine that calms the immune system, can lower the chance of developing pancreatitis (inflammation of the pancreas) after an ERCP procedure. ERCP is a procedure used to diagnose or treat problems in the bile ducts or pancreas.
This trial tests whether parecoxib or indomethacin works better at preventing pancreatitis, a common complication after a procedure called ERCP. Participants will receive one of the two medicines before the procedure, and the study will track which one is safer and more effective.
This trial is testing whether higher doses of a common anti-inflammatory drug (indomethacin) given as a suppository can better prevent pancreatitis after an ERCP procedure in people who are at high risk for this complication.
This study tests whether combining a rectal anti-inflammatory medication (indomethacin) with cold water cooling of the pancreas opening during an endoscopic procedure can better prevent pancreatitis—a painful inflammation of the pancreas—compared to medication alone.
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