Medicines to prevent pancreas swelling after ERCP
Treatments studied
Part of Digestive system clinical trials.
This Phase 3 study tests whether putting an anti-inflammatory medicine into the rectum (indomethacin) plus taking an immune-suppressing pill (tacrolimus) works better than using the two medicines in a different combination to prevent pancreatitis after an ERCP procedure. If you qualify, you may be assigned to one of the treatment options to lower your risk of post-ERCP pancreas inflammation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and having an ERCP at one of the participating centers
- You are able and willing to sign informed consent
- You are not pregnant and you are not breastfeeding
- You do NOT have standard reasons you cannot take indomethacin (an NSAID) or tacrolimus (a tacrolimus medicine)
- You are not using tacrolimus or other immune-modifying medicines right now
- You do not have serious kidney problems (very low kidney function or recent kidney injury) and you still have a rectum
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a rectal dose of indomethacin (an anti-inflammatory drug) can help prevent complications after an ERCP. It is for people who have already had a sphincterotomy and are having another ERCP to treat bile duct issues.
This trial tests whether using rectal NSAIDs (a type of painkiller) with or without a small tube (stent) in the pancreas can prevent pancreatitis after ERCP. It's for people who are at higher risk for this complication.
This trial tests if giving fluids before an ERCP procedure can lower the risk of developing pancreatitis (inflammation of the pancreas). It may help people who have not had this procedure before.
This trial tests whether a drug called tacrolimus can reduce the risk of pancreatitis (inflammation of the pancreas) after a procedure called ERCP, which is used to diagnose and treat problems in the bile ducts or pancreas. If you are scheduled for an ERCP, this study may help prevent a common complication.
This study tests whether adding ice water irrigation to standard rectal indomethacin reduces the risk of inflammation of the pancreas after ERCP, a procedure that examines the bile and pancreatic ducts. It may help prevent a painful complication.
This study tests giving indomethacin (a type of anti-inflammatory medicine) through the rectum in different doses to people having an ERCP (a procedure to look at bile and pancreas tubes), aiming to prevent a common complication called post-ERCP pancreatitis (inflammation of the pancreas). You may join if you are at high risk for this complication and meet the other health requirements.
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