Indomethacin to prevent complications after ERCP
Treatments studied
Part of Digestive system clinical trials.
This study tests whether a rectal dose of indomethacin (an anti-inflammatory drug) can help prevent complications after an ERCP. It is for people who have already had a sphincterotomy and are having another ERCP to treat bile duct issues.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You must be scheduled to have an ERCP (a procedure to look at and treat problems in your bile ducts) and have had a prior sphincterotomy (a small cut to widen the bile duct opening).
- You must be able to receive medication given rectally (as a suppository).
- You must be willing to follow study procedures and attend follow-up visits.
- You cannot be pregnant, breastfeeding, or unwilling to use birth control during the study.
- You must not have conditions that make it unsafe to take NSAIDs (like ibuprofen), such as a history of stomach ulcers, bleeding, or severe kidney problems, and you must not have chronic pancreatitis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests giving indomethacin (a type of anti-inflammatory medicine) through the rectum in different doses to people having an ERCP (a procedure to look at bile and pancreas tubes), aiming to prevent a common complication called post-ERCP pancreatitis (inflammation of the pancreas). You may join if you are at high risk for this complication and meet the other health requirements.
This study compares two common NSAID medications (indomethacin and diclofenac) given before an ERCP procedure to see if one is better at preventing pancreatitis, a common complication. If you are having an ERCP and meet the health criteria, you may be able to join.
This study tests whether adding ice water irrigation to standard rectal indomethacin reduces the risk of inflammation of the pancreas after ERCP, a procedure that examines the bile and pancreatic ducts. It may help prevent a painful complication.
This study compares indomethacin (an anti-inflammatory medicine) against using a temporary pancreatic stent to prevent pancreatitis after an ERCP procedure. It may help you lower the chance of painful inflammation of the pancreas after ERCP.
This study compares a low dose of indomethacin (a pain reliever) with the standard dose to see if it works just as well for preventing pancreatitis (inflammation of the pancreas) after an ERCP procedure. It may reduce side effects while still protecting your pancreas.
This Phase 3 study tests whether putting an anti-inflammatory medicine into the rectum (indomethacin) plus taking an immune-suppressing pill (tacrolimus) works better than using the two medicines in a different combination to prevent pancreatitis after an ERCP procedure. If you qualify, you may be assigned to one of the treatment options to lower your risk of post-ERCP pancreas inflammation.
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