Indomethacin vs Diclofenac before ERCP to prevent pancreatitis
Treatments studied
Part of Digestive system clinical trials.
This study compares two common NSAID medications (indomethacin and diclofenac) given before an ERCP procedure to see if one is better at preventing pancreatitis, a common complication. If you are having an ERCP and meet the health criteria, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 90 years old.
- You are scheduled for an ERCP and have not had your bile duct opening cut or stretched before.
- You are not allergic to NSAIDs (like ibuprofen or the study drugs).
- You have not taken any NSAID medication in the past 7 days.
- You do not have certain health problems that make NSAIDs unsafe (like recent stomach bleeding, kidney issues, or a bleeding disorder).
- You have not had acute pancreatitis in the last week and do not have severe pancreatic swelling or fluid collections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a rectal dose of indomethacin (an anti-inflammatory drug) can help prevent complications after an ERCP. It is for people who have already had a sphincterotomy and are having another ERCP to treat bile duct issues.
This study tests whether adding ice water irrigation to standard rectal indomethacin reduces the risk of inflammation of the pancreas after ERCP, a procedure that examines the bile and pancreatic ducts. It may help prevent a painful complication.
This trial tests whether rinsing the pancreas with cold water during ERCP can reduce the risk of pancreatitis, a common complication. The treatment is added to the standard medicine (indomethacin) to see if it offers extra protection.
This trial tests whether giving extra IV fluids before, during, and after an ERCP procedure can help prevent a common complication called post-ERCP pancreatitis (inflammation of the pancreas). If you are scheduled for an ERCP, you may be eligible to participate.
This study is looking at whether following a standard set of steps can lower the chances of a common complication after a procedure called ERCP, which is used to examine and treat problems in the bile ducts. The procedure involves inserting a thin tube through your mouth to reach the area, and the study aims to improve safety and reduce post-procedure pancreatitis (inflammation of the pancreas).
This trial tests whether taking indomethacin (an anti-inflammatory medicine) early can improve outcomes in people with acute pancreatitis. You might be eligible if your pancreatitis is diagnosed soon and you meet specific lab, imaging, and safety requirements.
Hear when a new ERCP trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.