Testing how a natural brain chemical causes headaches
Part of Pain clinical trials.
This study tests whether a natural chemical called substance P can trigger headaches in healthy people, to help researchers understand why some people get migraines. You'll receive an infusion and be monitored for any headache response — your participation could help improve future migraine treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 65 years old.
- You must weigh between 50 and 100 kg (about 110–220 lbs).
- You must have no history of any recurrent headache disorder (like migraine or cluster headaches), except for occasional mild tension headaches.
- No immediate family members (parents, siblings, children) with a history of recurrent headache disorders.
- You must not have any heart, blood vessel, or lung disease, and no past moderate/severe traumatic brain injury.
- No daily medication use (other than contraceptives) and no caffeine, nicotine, alcohol, or any headache in the 48 hours before your infusion visit.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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