Study of an experimental pill for chronic low back pain with leg pain
Part of Brain & nervous system, Pain clinical trials.
This study tests an experimental pill, AFA-281, for people with chronic low back pain that travels down the leg (sciatica). The pill aims to block a specific nerve signal that may reduce pain without the side effects of typical pain medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old
- You have had low back pain with leg pain (sciatica) for at least 3 months
- You have had an MRI or CT scan of your spine within the last year
- You are willing to stop current pain medications for a few weeks
- Your pain level is moderate to severe (4 to 9 on a 0-10 scale)
- You have not had surgery for this same leg pain
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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