Clin2
NCT06651853Possibly a fitRecruiting

Radiation therapy with lenalidomide and glofitamab for DLBCL

Diffuse Large B-cell LymphomaRelapsed and Refractory

Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.

This trial tests a combination of radiation therapy, lenalidomide, and glofitamab for people with a type of lymphoma called DLBCL that has not responded to or has returned after initial treatment. The goal is to see if this combination can help when other treatments have failed.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
22 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be at least 18 years old.
  • You must have a type of lymphoma called diffuse large B-cell lymphoma (DLBCL) that has come back or not responded to standard treatment.
  • You must have at least one tumor that can be measured on scans.
  • You must not have received a bispecific antibody therapy before.
  • Your major organs (like liver, kidneys, bone marrow) must be working well enough based on blood tests.
  • You must be able to swallow oral medications.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07702851Not yet recruiting· Phase 2
Study of two new drugs for people with large B-cell lymphoma that returned or didn't respond to first treatment

This trial tests a combination of two targeted drugs, polatuzumab vedotin and glofitamab, for people with large B-cell lymphoma that came back or didn't go away after their first standard treatment. The goal is to see if this combination can help control the lymphoma.

NCT07528352Recruiting· Phase 1
Radiation Plus Antibody Therapy for Difficult-to-Treat Lymphoma

This trial tests a combination of radiation therapy to specific tumor sites followed by a bispecific antibody (a type of immunotherapy that targets cancer cells). It's designed for people with diffuse large B-cell lymphoma that has not responded to or has come back after at least two prior treatments.

Salt Lake City, Utah
NCT07749365Recruiting· Phase 2
Combination therapy for newly diagnosed brain lymphoma

This trial tests a combination of radiation, immune-boosting drugs, and a targeted antibody for people newly diagnosed with primary central nervous system diffuse large B-cell lymphoma (a type of brain lymphoma). The goal is to see if this approach is safe and effective.

Xiamen, Fujian
NCT07634289Not yet recruiting· Phase 2
Radiation plus glofitamab for large B-cell lymphoma

This trial combines a targeted antibody treatment called glofitamab with radiation therapy for people whose diffuse large B-cell lymphoma has come back or not responded to previous treatments. It aims to see if this combination can help control the disease.

Douglas, Queensland
NCT06867536Recruiting· Phase 2
Radiation plus glofitamab for relapsed large B-cell lymphoma with large tumors

This trial tests whether combining a short course of radiation with a targeted antibody drug (glofitamab) can help people with aggressive large B-cell lymphoma that came back after treatment, especially if they have bulky tumors. It aims to find a new option for hard-to-treat cases.

Wuhan, Hubei
NCT06050694Recruiting· Phase 2
Testing glofitamab plus chemo for untreated DLBCL

This trial tests a new drug called glofitamab combined with standard Pola-R-CHP chemotherapy for people with untreated DLBCL. The goal is to see if using PET scans and blood tests early on can guide treatment and improve outcomes.

Toronto, Ontario

Hear when a new Diffuse Large B Cell Lymphoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.