Study of ACTG2 gene changes in children with intestinal blockage
Part of Digestive system clinical trials.
This study looks at how changes (mutations) in a gene called ACTG2 affect the muscles that move food through the gut in children and adults with a rare condition called pediatric intestinal pseudo-obstruction (PIPO). It may help researchers understand the condition better and find new ways to help patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 4 years old or older
- You were diagnosed with pediatric intestinal pseudo-obstruction (PIPO) before age 18
- You have at least 2 out of the standard criteria for PIPO (as defined by doctors) and carry a specific change in the ACTG2 gene (types: R178, R257, R40, or A136)
- You or your guardians agree to take part and sign a consent form
- You are part of the French Social Security system or have equivalent health coverage
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial checks if a genetic test can find causes of a rare condition where the intestines don't move normally, causing blockages. It may help people with poor esophagus muscle function.
This trial tests how well a new enzyme treatment (cipaglucosidase alfa with miglustat) works and how safe it is in children and babies with infant-onset Pompe disease. It may help by improving muscle function after earlier treatment or, for some babies, starting treatment when no prior enzyme therapy has been given.
This trial tests a new drug, TPST-1495, to reduce the number of benign polyps in the small intestine for people with a condition called familial adenomatous polyposis (FAP). If you join, you will likely not know if you receive the drug or a placebo, to see if the drug is helpful.
This study tests a new way to take a deeper tissue sample (biopsy) from the intestine during an endoscopy to better understand chronic intestinal pseudo-obstruction. The goal is to find out if it's safe and helpful for people like you.
This study tracks the health of people with a confirmed ACTA2 gene change over time to better understand the disease. It may help researchers learn how to improve care for this condition.
This study looks at how the csgA gene changes over time in people with Parkinson's disease, especially if they have stomach or bowel issues. It aims to help understand how these changes might relate to symptoms.
Hear when a new PIPO trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.