CD19 UCAR T cells for severe lupus
Part of Immune system & allergy, Skin clinical trials.
This trial tests an experimental treatment called CD19 UCAR T cells for people with severe lupus that hasn't gotten better with standard medicines. It aims to see if these special immune cells can safely and effectively control the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 5 years old or older.
- You have been diagnosed with lupus (SLE) and still have moderate to severe symptoms despite trying at least 3 months of high-dose steroids, hydroxychloroquine, and at least two other lupus medications.
- Your lupus disease activity score (SLEDAI-2K) is 8 or higher.
- Your major organs are working well enough, as shown by tests like heart ultrasound, kidney function, and liver blood tests.
- You have not had CAR T-cell therapy before, and you do not have an active infection like tuberculosis or HIV.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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