Gut bacteria transplant for depression not helped by escitalopram
Treatments studied
Part of Mental health clinical trials.
This trial tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with depression that does not respond well to the antidepressant escitalopram. You will first take escitalopram for 2 weeks, and if it doesn't help enough, you may receive either the real transplant or a placebo capsule.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with major depression (recurrent or a single episode).
- You are not currently taking any antidepressant for this episode.
- You are willing to start the antidepressant escitalopram (Lexapro).
- Your depression does not improve enough after 2 weeks of escitalopram (less than 20% reduction in symptoms).
- You are able to swallow capsules and have no serious gut problems or recent antibiotic use.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether escitalopram, a common antidepressant, helps people who are experiencing their first episode of depression and have never taken medication for it. It also looks at how the drug works in the brain.
This trial tests whether a probiotic supplement can help reduce symptoms of moderate to severe depression. If you have not responded to or are not taking antidepressants, this study might offer a new option.
This study tests whether a stool transplant from a healthy donor can help treat depression. It aims to see if improving gut bacteria can improve mood and depression symptoms.
This trial tests whether adding a special fish oil supplement (CreNeuroS) to the antidepressant escitalopram helps improve depression symptoms more than escitalopram alone. If you have moderate to severe depression and are starting or recently started escitalopram, this study may help you find a more effective treatment.
This trial tests if probiotics can help reduce symptoms of mild to moderate anxiety or depression. It is for people aged 18–60 who are not currently taking most anxiety or depression medications and who have not used them in the last 2 weeks (except for escitalopram).
This trial tests whether taking capsules containing freeze-dried healthy donor stool can improve symptoms of irritable bowel syndrome (IBS) that haven't gotten better with usual treatments. It aims to see if this approach is safe and helpful for people with moderate to severe IBS.
Hear when a new Depression - Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.