Gut bacteria transplant for depression not helped by escitalopram
Treatments studied
Part of Mental health clinical trials.
This trial tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with depression that does not respond well to the antidepressant escitalopram. You will first take escitalopram for 2 weeks, and if it doesn't help enough, you may receive either the real transplant or a placebo capsule.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with major depression (recurrent or a single episode).
- You are not currently taking any antidepressant for this episode.
- You are willing to start the antidepressant escitalopram (Lexapro).
- Your depression does not improve enough after 2 weeks of escitalopram (less than 20% reduction in symptoms).
- You are able to swallow capsules and have no serious gut problems or recent antibiotic use.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests whether escitalopram, a common antidepressant, helps people who are experiencing their first episode of depression and have never taken medication for it. It also looks at how the drug works in the brain.
This trial tests whether fecal microbiota transplantation (FMT, a stool-based treatment that changes gut bacteria) can improve symptoms of first-episode depression. It’s mainly for adults with moderate-to-severe depression based on a common symptom score.
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This trial tests whether taking capsules containing freeze-dried healthy donor stool can improve symptoms of irritable bowel syndrome (IBS) that haven't gotten better with usual treatments. It aims to see if this approach is safe and helpful for people with moderate to severe IBS.
This trial studies whether fecal microbiota transplantation (a procedure that transfers gut bacteria) can improve symptoms in people with schizophrenia. It may help by changing the gut microbiome, which researchers think could affect brain and behavior symptoms.
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