Comparing two chemotherapy plans after surgery for bile duct cancer
Treatments studied
Part of Cancer clinical trials.
This study compares two chemotherapy approaches for patients whose bile duct or gallbladder cancer has been removed but who have a higher chance of it coming back. One group gets a combination of two chemotherapy drugs through an IV, and the other gets a chemotherapy pill. The goal is to see which treatment better prevents recurrence.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You had surgery to remove your bile duct or gallbladder cancer, and the surgeon was able to remove all visible cancer (clear margins).
- After surgery, the lab found at least one high-risk feature, such as cancer in lymph nodes or spread into blood vessels or nerves.
- You have not had chemotherapy before.
- You are generally active and able to care for yourself (ECOG score 0 or 1).
- Your blood counts and liver/kidney function are within acceptable levels.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of three drugs (irinotecan liposome, capecitabine, and lenvatinib) for people with advanced bile duct or gallbladder cancer that has grown despite previous treatment. The goal is to see if this new combination can help shrink tumors or slow down the cancer.
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This trial tests a personalized cancer vaccine combined with chemotherapy to help prevent bile duct cancer from coming back after surgery. It is for people who had their tumor removed but have a high risk of recurrence.
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This trial tests a chemotherapy approach after surgery for bile duct or gallbladder cancers. The goal is to see if giving chemotherapy based on a detailed analysis of your tumor (called 3D-PTA) helps prevent the cancer from coming back.
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