Clin2
NCT06703398Possibly a fitRecruiting

Study of GC101 TIL for advanced melanoma

Melanoma

Part of Cancer, Skin clinical trials.

This trial tests a new treatment called GC101 TIL for people with advanced melanoma that has not responded to other therapies. It involves taking immune cells from a tumor, growing them in a lab, and giving them back to fight the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
98 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are between 18 and 75 years old.
  • You have advanced, recurrent, or metastatic melanoma that cannot be removed by surgery, but not melanoma that started in the eye.
  • Your melanoma has not responded to or has stopped responding to PD-1 antibody treatment.
  • You have failed at least two prior treatments for your melanoma. If you have a BRAF mutation, you must have tried a BRAF/MEK inhibitor. If you have an NRAS mutation, you must have tried Tunlametinib.
  • You have at least one tumor that can be surgically removed to collect immune cells, and another tumor that can be measured after the procedure.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07028008Not yet recruiting
TIL therapy for advanced melanoma after immunotherapy

This trial tests a personalized cell therapy using your own immune cells (TILs) grown in a lab. It is for people with advanced melanoma that did not respond to or stopped responding to prior immunotherapy.

NCT06204991Recruiting· Phase 1
T-cell therapy for advanced melanoma

This trial tests a new treatment called ADP-TILIL7 for people with advanced melanoma. It uses your own immune cells (T-cells) that are taken from a tumor, multiplied in a lab, and then given back to you to fight the cancer. The goal is to see if this treatment is safe and works better than standard options.

Herlev
NCT02621021Recruiting· Phase 2
Immune cell therapy for advanced melanoma

This trial tests a treatment that uses your own immune cells, called tumor-infiltrating lymphocytes (TILs), to fight melanoma. Some participants also get a drug called pembrolizumab. The goal is to see if this approach can shrink tumors.

Bethesda, Maryland
NCT06961357Recruiting· Phase 1/Phase 2
CD40L-Enhanced TIL therapy for advanced melanoma

This trial tests a new way to treat advanced melanoma by taking immune cells from your tumor, enhancing them in the lab to fight better, and giving them back to you. It is for people whose melanoma has spread or cannot be removed, and who have already tried standard treatments.

Tampa, Florida
NCT06941818Enrolling by invitation· Phase 1
TIL therapy for advanced melanoma

This trial tests a new cell therapy made from your own tumor-fighting cells (TILs) for advanced melanoma that hasn't responded to other treatments. It aims to shrink tumors by re-infusing these boosted cells back into your body.

Beijing
NCT07310784Recruiting· Phase 2
Testing LM103 for advanced melanoma

This trial tests a new drug called LM103 for people with advanced melanoma who have already tried several standard treatments, including immunotherapy. The goal is to see if LM103 can help shrink tumors when other treatments have stopped working.

Beijing, Beijing Municipality

Hear when a new Melanoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.