TIL therapy vs chemo for advanced melanoma
Part of Cancer, Skin clinical trials.
This trial tests a personalized cell therapy using your own immune cells (tumor-infiltrating lymphocytes, or TILs) to fight advanced melanoma that has stopped responding to standard treatments like anti-PD-1 (immunotherapy). If you qualify, you'd receive your own TILs instead of chemotherapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have advanced melanoma that has spread or come back, and it has gotten worse after anti-PD-1 (immunotherapy) and other standard treatments.
- You have at least one tumor that can be surgically removed (at least the size of a pea) to make the TIL cells. That tumor must not have been treated with radiation or other local therapy in the last 28 days.
- You have at least one other measurable tumor after the tissue is taken for the TILs.
- You are in fairly good health (able to do daily activities with little help), with normal heart, lung, and blood functions, and no serious infections or autoimmune diseases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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