Propranolol added to usual care for hard-to-control focal seizures
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests whether adding a common blood pressure medicine, propranolol, to your usual seizure medicines can reduce hard-to-control focal seizures (seizures that start in one part of the brain). If you have had focal seizures for at least 2 years that haven't improved with two or more seizure drugs, this trial may offer a new option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old.
- You have focal seizures (starting in one area of the brain) that sometimes spread to both sides, and they last at least 1 minute with some loss of awareness.
- You have tried at least two seizure medicines without good control for at least 2 years, and your current seizure medicines have been stable for at least 12 weeks.
- You have had at least 6 focal seizures in the past 12 weeks.
- You have had an EEG or brain scan (MRI or CT) in the past 2 years that supports the diagnosis of focal epilepsy.
- If you have a vagus nerve stimulator or deep brain stimulator, it must be in place for at least 5 months and stable for 12 weeks before starting.
- You do not have certain heart, lung, or other medical conditions that would make propranolol unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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