Sirolimus for hard-to-treat focal epilepsy
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests if the drug sirolimus can help people with focal seizures (starting in one part of the brain) that don't improve with at least two other medications. It aims to reduce seizure frequency in adults aged 18 to 60.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old.
- You have focal seizures (starting in one area of the brain) or focal seizures that spread to both sides.
- Your epilepsy has not been controlled by at least two anti-seizure medications for the past 2 years.
- You have had at least 6 focal seizures in the last 12 weeks, each lasting 1 minute or more with altered awareness.
- You have had an EEG or brain scan in the last 2 years confirming focal epilepsy.
- You cannot be pregnant, breastfeeding, or have certain other medical conditions like severe heart, liver, or immune problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a non-invasive focused ultrasound treatment for people with epilepsy that doesn't respond to medications. The goal is to see if this gentle ultrasound can reduce seizures without surgery.
This study tests whether the medicine everolimus (taken as a pill) can safely reduce seizures in adults with focal epilepsy that hasn't been controlled by other treatments. You would continue your current seizure medicines and add everolimus.
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
This Phase 3 study tests whether sirolimus helps control complex vascular anomalies that have not responded to standard treatments. It also checks safety by monitoring blood tests, organ function, and overall health during treatment.
This trial tests whether sirolimus, a medication that may slow blood vessel changes, can help people with a condition called vertebrobasilar dolichoectasia (VBD), where a major artery in the brain becomes enlarged and twisted. If you have had symptoms or a stroke related to VBD, this study might offer a new treatment option.
This trial tests a non-invasive treatment for hard-to-control epilepsy. Using MRI guidance, sound waves are focused on a small area in the brain to reduce seizures, offering a possible alternative to open surgery.
Hear when a new Epilepsy, Drug Resistant trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.